The electric potential of healthy cells (measured between the cell core and the outer surface of the cell membrane) is -175mV and that of cancer cells 0 to -10 mV. Tumour cells therefore differ significantly from healthy cells. Due to their different electrical potentials, cells (tissues) have different electrical conductivities and resistances.
This fact is exploited in electro cancer therapy (ECT), in which a weak direct current is applied to the tumour tissue via electrodes. The most important changes in biological tissues in the vicinity of the electrode are connected with the ongoing reduction and oxidation processes, that is, with OH- and H+ in equilibrium. The negative electrode causes oxidation of the hydrogen ions, which causes intense hydrogen gas production and therefore an alkaline area arises in the vicinity of the negative electrode caused by the escaping hydrogen gas (decreased hydrogen ion concentration). In the reduction process, the OH- radicals are concentrated in the vicinity of the positive electrode (in the form of H3O2- and H/O4- hydrated clusters) and cause the area around the electrode to become acidic. Almost no gas is produced at this electrode in this process.
One or more pairs of electrodes are applied, depending on the size of the tumour area. The current is applied even while the electrodes are being inserted. The purpose of this action is to capture any detached tumour cells in the dielectric field so as to prevent a spread (metastasis).
During therapy, the patient is a constantly visually monitored. The course of therapy is computer-controlled and monitored. Significant negative side effects are virtually eliminated and have never yet been observed. After treatment, the patient is usually able to go home independently.
The mechanism of electrical conduction in biological tissues (both in living and in non-living tissues) is very complicated and even today is still not fully understood. The characteristic feature of the process is forced ion transfer. It is the most important process in cancer treatment for achieving definitive damage to malignant tissue (galvanic process).
Resistance is highly dependent on geometric relationships and on the material through which the current flows. This causes a problem for measurement in the living body because actual loads are not characteristics of the tissue. A mixed series of effects are present at the same time. This is the reason why experiments to determine the specific tissue effects have started and the results have diverged from the geometric research.
A method has been developed that is successful both diagnostically and therapeutically. The parameters actually required for management are the characteristic resistance data from measured resistances at different electrode depths. At a depth of x, the resistance is given in the form of a third degree polynomial:
R (x) = Ro + R1x + R2x2 + R3x3
Here we get a constant as a result. Working from this we can separate the geometric parameters of the penetrating electrodes and measure the resistances of the needle tip and needle sheath.
The most important principle is the physical and chemical destruction of the cancerous tissue with well-planned, focussed effects without serious penetration into healthy tissue. This destructive mechanism applies all the aforementioned properties of direct current optimised in the interests of achieving a better outcome. The course of therapy and patient management are properly controlled and recorded by computer.
Patient data can be accessed by the treatment staff so they can select the optimum parameters for the treatment. Details are constantly documented during treatment and information is processed so that the most effective path is indicated. Impermeability of tissue is the physical parameter with the best measurement results of effectiveness. The charge passed is measured in Coulomb C (unit of charge). Minus 1 Coulomb (C) is equivalent to approx. 6.242*1018 electrons, or 1 Coulomb = 1 Ampere (A) * 1 second (sec.) (this means that 1 Coulomb is the electric charge that is transported within one second through an electric conductor, in which an amperage of 1 ampere flows).
Furthermore, ionisation is known to have a positive effect. The current is passed on both through the ions of the tissue and those induced by the external current. This has a huge effect: the radioactivity unit 1 Roentgen (1R) defines the 0.258 C / cm3 unit (0.108 erg / cm3 - 93.1 ergs/gr or in other words 0,869 rad) determined by the ion pair production. This value is produced already at 129 mA, assuming that both ions participating in the process are formed by the electric power supplied. Current here simulates radioactive ionisation - but in a better way than via irradiation, because ionisation only occurs with those molecules that are soluble in an aqueous substance, and their disassociation is supported by the electric field. This means that the galvanic effect is a specific ionisation process where the ionisation is far more selective than with irradiation.
An overview of treatable types of tumours and contra indications is provided here.